Monday, August 12, 2024

Aug 12, 2024 - Covid variant JN.1 may have become dominant due to just one mutation - New Scientist (No paywall)

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Visualizing the Cost of Insulin in the United States (2004-2024)

So what drove the cost of insulin? The complex answer involved pharmacy benefit managers (PBMs), third-party organizations who negotiate drug prices on behalf of insurance companies, employers, and government programs. They negotiate discounts and rebates with the drug manufacturers (paying a reduced price), but in most cases the patients are charged the list price.

This enticement of rebates, and a lack of competition, caused prices to climb unchecked. Whether the extra cost paid by patients went to PBMs, insurance companies, or drug manufacturers depended on the specific drug system and contract, part of the call for greater transparency in the market.

Continued here


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Covid variant JN.1 may have become dominant due to just one mutation - New Scientist (No paywall)  
  

“A single mutation in JN.1 was key for it to evade the antibody response, and that’s why it was able to spread globally,” says Emanuele Andreano at the Toscana Life Sciences Foundation in Italy.


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Five of the most important International Space Station experiments - New Scientist (No paywall)  
  

It’s not all eating bits of food floating in mid-air and introducing suction toilets to fascinated Earthlings – crews on the International Space Station (ISS), which will be coming to an end soon, have serious work to do.






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On a journey through the lakelands of Austria's Carinthia region - Travel (No paywall)  
  

There are seven lakes with pristine, drinking-quality water in the region of Klopeiner See–Südkärnten–Lavanttal, the easternmost part of Carinthia. The bathing season starts in May, when the lakes become hubs for water activities: swimming, stand-up paddleboarding, canoeing, boating and fishing.


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Cynthia Chiang is searching for signs of the universe's first light - Impact (No paywall)  
  

“It was written in some sense,” that National Geographic Explorer Cynthia Chiang would end up in observational cosmology — the study of the origin and development of the universe using specialized detectors and telescopes. “I’m not going to lie, my father was a physicist. My mother’s an astronomer. But no kid wants to be like their parents,” she jokes, semi-seriously.




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Ukraine's shock raid deep inside Russia rages on - The Economist (No paywall)  
  

THE SOLDIERS chanted the Lord’s Prayer and clicked rosary beads as they advanced. For Ivan, 43, an old-timer from Ukraine’s 103rd brigade, the fighting inside Russia was just another day’s work. “Grenades and mortars look the same wherever you are.” The newest recruits were almost paralysed with fear. But the men tramped on together, 10km a day, crossing fields and railway lines, every night replacing forward units in hastily dug positions ahead of them. Three days, three hikes, three rotations. On the third night, the Russian glide bombs hit. “Everything was burning. Arms here, legs there”. Twelve men in the company died immediately. Ivan suffered shrapnel injuries to his groin and chest, and was evacuated to a hospital in the Sumy region of Ukraine.


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Would building 1.5m homes bring down British house prices? - The Economist (No paywall)  
  

HOMES IN Britain have become eye-wateringly expensive. When the Labour Party last won power, in 1997, the ratio of the median house price to the median income in England was 3.5. Now it is 8.3. The share of households aged under 30 who own their own home has fallen from one in five in 1997 to one in eight. On July 24th Sir Keir Starmer, the new prime minister, said that Britain’s failure to build was denying young people “the basic dream of homeownership”.




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An Early-Stage VC Explains the Recipe for Strong IPO Candidates in 2024 - Inc.com (No paywall)  
  

When you consider companies with bright IPO prospects, what image comes to mind? Facebook rose to gargantuan status as it gobbled up users unlike any social platform before it, going public in 2012. But establishing vast usership--like Uber, or even like Bird did in its early days--and growing at a dizzying clip isn't what's catching investors' imaginations these days. 


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Atop Inflation, Rising Credit Card Debt May Be Causing Consumers to Tighten Spending - Inc.com (No paywall)  
Atop Inflation, Rising Credit Card Debt May Be Causing Consumers to Tighten Spending - Inc.com (No paywall)&url=https://archive.ph/ikf1U&hashtags=tradebriefs&via=TradeBriefs">  

If retail business owners notice shoppers agonizing even more than usual about making a purchase, it's probably not just the effects of two straight years of relentless, inflation-driven price hikes. Consumers now carry record-high levels of credit card debt, resulting in payment delinquency levels not seen since 2012, hardly a signal of a coming spending boom. 




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Zaporizhzhia nuclear plant fire: what we know so far  
  

The nuclear plant—Europe's largest—has been under Russian control since early March 2022, just days after Russian President Vladimir Putin's full-scale invasion of Ukraine began. It was one of the first sites to be seized by Russian forces.


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The "It Ends With Us" drama is the new "Don't Worry Darling" drama  
  

You might have seen previews or even bought tickets for the new film adaptation of Colleen Hoover’s best-selling romance novel It Ends With Us, starring Blake Lively. But have you heard about the online soap opera surrounding a rumored rift among the film’s cast, its director and co-star Justin Baldoni, and possibly Deadpool? Once again, a film’s press tour is already stirring up more conversation than the movie itself.




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Paris reminded us why we love the Olympics  
  

And guess what else? The many Parisians who stayed embraced Olympic fervor, cheering on the sporting exploits of Team France, from swimmer Leon Marchand (who dominated the pool in Michael Phelps-esque style) to its pole vaulters (somewhat less successful).


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The 7 States That Will Decide the Election  
  

Every four years we resketch our U.S. electoral maps of the most competitive states. Some states fall out of favor. (Sometimes wrongly. Hi, Ohio and Florida.) Others come online. (Hello, Georgia.) Yet others rekindle their battleground flames. (You up, North Carolina, Virginia, or even New Hampshire?)




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Memorable Moments from the 2024 Olympics Closing Ceremony  
  

The first half of the program was made up of acts that paid tribute to the host country and French culture, while the second half was more “Hollywood,” as the next summer Olympics will take place in Los Angeles in 2028.


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Family of Isaac Hayes threaten Donald Trump with lawsuit over use of song in rallies  
  

Trump frequently used Neil Young’s Rockin’ in the Free World at rallies, prompting the Toronto-born musician to write an open letter in 2020 in which he acknowledged he didn’t have legal recourse to block the use, but stated: “You are a disgrace to my country … Your mindless destruction of our shared natural resources, our environment and our relationships with friends around the world is unforgivable.”




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Warren Buffett Bought $9.2 Billion of This Stock Last Year, but He's Suddenly No Longer Interested  
  

Bank of America is an advertising partner of The Ascent, a Motley Fool company. Adam Levy has positions in Apple. The Motley Fool has positions in and recommends Apple, Bank of America, and Berkshire Hathaway. The Motley Fool has a disclosure policy.


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Prediction: 2 Stocks Warren Buffett Is Selling That Wall Street Doesn't Know About  
  

Bank of America is an advertising partner of The Ascent, a Motley Fool company. Sean Williams has positions in Bank of America. The Motley Fool has positions in and recommends Apple, Bank of America, Berkshire Hathaway, and Chevron. The Motley Fool recommends Occidental Petroleum. The Motley Fool has a disclosure policy.




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BMW, Chrysler, Toyota among 142K vehicles recalled last week: Check car recalls here  
  

Ahjané Forbes is a reporter on the National Trending Team at USA TODAY. Ahjané covers breaking news, car recalls, crime, health, lottery and public policy stories. Email her at aforbes@gannett.com. Follow her on Instagram, Threads and X (Twitter) @forbesfineest.


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Billionaire Gautam Adani's Fortune Slips Again After Hindenburg Report Targets Indian Regulator - Forbes (No paywall)  
  

Shares of Adani Group's listed firms slumped on Monday after the Hindenburg Group published a report over the weekend accusing the Indian market regulator's chief of a conflict of interest that allegedly prevented a proper investigation into the American short seller's earlier claims of fraud and stock manipulation by the conglomerate.


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An Artistic Mission, Sustained by 'the Packers Fans of Theater'  
  

That last is partly a practical choice since A.P.T. productions — nine this season, with the last closing on Nov. 10 — are done in repertory. This means the actors are always busy rehearsing or performing, leaving little spare time to add microphones to tech rehearsals. But banking on the glory of the human voice is primarily an artistic decision: Nothing comes between the actors, their words and the public.


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I.V.F. Threats in Alabama Drive Clinics to Ship Out Embryos  
  

While there is no official tally of the number of frozen embryos in the United States, experts estimate it’s in the millions. And many clinics are overwhelmed by a mounting inventory of cells that are sometimes years or even decades old.


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Opinion | The Science That Put This Man on Death Row Has Been Debunked. He's About to Be Executed Anyway.  
  

Last year, for the first time, a Gallup poll found that more Americans believe the death penalty is administered unfairly than fairly (50 percent versus 47 percent). And the percentage of people who support the death penalty has fallen steadily since the mid-1990s, according to Gallup, dropping to 53 percent this year, a five-decade low.


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Linda Reynolds believed Lehrmann rape trial was politically motivated, psychologist tells defamation trial  
  

Information and support for anyone affected by rape or sexual abuse issues is available from the following organisations. In Australia, support is available at 1800Respect (1800 737 732). In the UK, Rape Crisis offers support on 0808 500 2222. In the US, Rainn offers support on 800-656-4673. Other international helplines can be found at ibiblio.org/rcip/internl.html


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'Morally insane' Wieambilla killers believed in plot to turn humans into 'meat suits', inquest hears  
  

In Australia, the crisis support service Lifeline is 13 11 14 and the Kids Helpline is 1800 55 1800. In the UK and Ireland, Samaritans can be contacted on freephone 116 123, or email jo@samaritans.org or jo@samaritans.ie. In the US, you can call or text the National Suicide Prevention Lifeline on 988, chat on 988lifeline.org, or text HOME to 741741 to connect with a crisis counsellor. Other international helplines can be found at befrienders.org


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Move Over, Nvidia and Broadcom: Wall Street Has a New Artificial Intelligence (AI) Stock-Split Stock  
  

Sean Williams has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Chipotle Mexican Grill, Nvidia, and Walmart. The Motley Fool recommends Broadcom and recommends the following options: short September 2024 $52 puts on Chipotle Mexican Grill. The Motley Fool has a disclosure policy.


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Prediction: Nvidia Will Jump Over 20% By the End of 2024 After Its Big Sell-Off  
  

Here's why a big rebound could be in store for Nvidia.


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Stocks Falter as Traders Brace for Big Data Week: Markets Wrap  
  

In commodities, oil extended its first weekly gain since early July, with traders continuing to monitor Iran’s response to last month’s assassination of a Hamas leader in Tehran. Gold edged higher, with traders focused on the week’s key US data.


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Billionaires Are Selling Nvidia Stock and Buying 1 Supercharged Index Fund for the Artificial Intelligence (AI) Boom  
  

Several hedge fund managers have been buying shares of the Invesco QQQ Trust, an index fund with AI stocks like Apple, Microsoft, Alphabet, and Amazon.


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3 Reliable Dividend Stocks With Yields Above 5% That You Can Buy With $100 Now  
  

Cory Renauer has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Pfizer. The Motley Fool recommends Verizon Communications. The Motley Fool has a disclosure policy.


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Bitcoin Signals Potential Bottom as Market Indicators Turn Bullish  
  

BTC is currently trading at $58,681, down 3.8% over the past 24 hours after having lost the $60,000 level. However, Bitcoin gained 7.58% over the past 7 days after a strong recovery from the lows of $49,500.


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When is the best time to do a Roth IRA conversion? Here's how to make the most of this potentially tax-savvy move.  
  

For someone who’s already thinking about a Roth conversion, “down markets can be an attractive time,” Tierney said, as there’s potentially a chance to “convert the same amount of shares for a lower tax bill.”


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Is It Too Late to Buy Palantir Technologies Stock?  
  

Stock Advisor provides investors with an easy-to-follow blueprint for success, including guidance on building a portfolio, regular updates from analysts, and two new stock picks each month. The Stock Advisor service has more than quadrupled the return of S&P 500 since 2002*.


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Is Now the Time to Buy Energy Transfer Stock?  
  

Geoffrey Seiler has positions in Energy Transfer, Enterprise Products Partners, and Western Midstream Partners. The Motley Fool has positions in and recommends Moody\'s. The Motley Fool recommends Enterprise Products Partners. The Motley Fool has a disclosure policy.


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Prediction: This CEO of a Boeing and Lockheed Joint Venture Sees Billions of Dollars in His Future  
  

John Mackey, former CEO of Whole Foods Market, an Amazon subsidiary, is a member of The Motley Fool\'s board of directors. Rich Smith has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Amazon. The Motley Fool recommends Lockheed Martin. The Motley Fool has a disclosure policy.


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Can NIO Succeed Where Rivals Have Failed? So Far, So Good.  
  

Stock Advisor provides investors with an easy-to-follow blueprint for success, including guidance on building a portfolio, regular updates from analysts, and two new stock picks each month. The Stock Advisor service has more than quadrupled the return of S&P 500 since 2002*.


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The FDA should withdraw approval of more than 400 tainted medicines  
  

Suzanne Robotti is the founder and president of MedShadow Foundation, a nonprofit organization focused on researching and explaining the hidden and minimized side effects of over-the-counter and prescription drugs, and has been a consumer representative on the FDA’s Drug Safety and Risk Management Committee since 2017.


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Some 'inconvenient' truths about pharmacy benefit managers  
  

T. Joseph Mattingly II is an associate professor of pharmacotherapy at the University of Utah College of Pharmacy. David A. Hyman is the Scott K. Ginsburg Professor of Health Law & Policy at Georgetown Law School. Ge Bai is a professor of accounting at the Johns Hopkins University Carey Business School and a professor of health policy and management at the Johns Hopkins Bloomberg School of Public Health.


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What's in a drink? U.S. regulators consider new alcohol label, but health advocates want even more  
  

Isabella Cueto covers the leading causes of death and disability: chronic diseases. Her focus includes autoimmune conditions and diseases of the lungs, kidneys, liver (and more). She writes about intriguing research, the promises and pitfalls of treatment, and what can be done about the burden of disease.


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She's Fighting Big Oil in Texas. But Republicans Want to Make Her D.A.  
  

But concerns about crime and potential human trafficking in the area prompted Ms. Stogner to step up. Her entrance as a Republican challenger means that for the first time since 2008 there will be an actual contest for the top prosecutor job in a corner of Texas where fears about crime are often addressed by carrying a sidearm.


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Harris Appeals to Tech Leaders in a Return to San Francisco  
  

Mr. Biden struggled for financial support from the Bay Area dating to his 2020 presidential campaign, when his list of fund-raisers was heavy on Obama-era ambassadors but light on the billionaire leaders of the tech industry.


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White House launches broad new regulatory effort, as Harris prepares to unveil economic plan  
  

None of the actions that make up the \"Time is Money\" initiative will require congressional approval, a senior administration official said. Republicans currently control the House of Representatives, and any new consumer protection bills would face long odds.


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'This will make them scream': Alfred Hitchcock on his film-making secrets  
  

For more stories and never-before-published radio scripts to your inbox, sign up to the In History newsletter, while The Essential List delivers a handpicked selection of features and insights twice a week.


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Water companies set to pay more compensation for poor service  
  

They will also more than double the payments for certain highly disruptive incidents, such as failing to provide notice of supply interruptions and missing arranged appointments with customers.


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Brands Love Influencers (Until Politics Get Involved)  
  

Viral Nation, another influencer agency, also offers marketers a product that makes “risk profiles” for creators. The tool, which the company has been using for more than year, assesses years of posts — including hours of dialogue from videos — and can detect whether people are holding weapons or protest signs in their content, even if those elements aren’t mentioned in captions or audio.


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Uber, Facing Sexual-Assault Litigation, Pushes Plan That May Curb Suits  
  

The PAC has presented the measure as a way to protect people from trial lawyers who are “getting rich at the expense of plaintiffs and everyone else,” as the group says on its website alongside a picture of someone sliding a $100 dollar bill into a suit pocket.


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Los Angeles, Next Up for Summer Olympics, Hopes to Turn a Profit  
  

For the current mayor, Karen Bass, hosting the Olympics is more than an opportunity to showcase familiar attractions like Hollywood or Venice Beach. It’s also about connecting visitors with small businesses citywide.


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Spain Is Thirsty. Here's How It Gets Water.  
  

The Torrevieja plant is the largest of its kind in Europe, and similar plants dot the Spanish coastline. They have helped to enable rampant coastal development in parched areas and to support an agricultural industry that is considered among the world’s most proficient at managing water.


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Britain's Anti-Immigrant Riots Pose Critical Test for Starmer  
  

Concern over immigration, which declined in Britain after Brexit, is on the rise again and, when jobs are scarce and health care and other services are overstretched, immigrants make an easy target for the far right. The campaign leading up to last month’s general election prompted a bitter political dispute over the last government’s plans to send to Rwanda people arriving in Britain on small boats.


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U.S. and Israeli Defense Officials Speak Amid Fears of Escalation in Mideast  
  

Eric Schmitt is a national security correspondent for The Times, focusing on U.S. military affairs and counterterrorism issues overseas, topics he has reported on for more than three decades. More about Eric Schmitt


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Opinion | The Harris-Walz Ticket Is Our Opportunity for Political Imagination  
  

The candidates are creating space for our most extravagant imaginings.




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